5-Chloro-2-nitroanisole

CAS: 6627-53-8

Ref. TR-C377695

Produktinformation

• Name: 5-Chloro-2-nitroanisole
• Synonyme: 4-Chloro-2-methoxy-1-nitrobenzene, 1-Chloro-3-methoxy-4-nitrobenzene, 2-Methoxy-4-chloronitrobenzene, 2-Nitro-5-chloroanisole, 3-Methoxy-4-nitro-1-chlorobenzene, 4-Chloro-2-(methyloxy)-1-nitrobenzene, 4-Chloro-2-methoxy-1-nitrobenzene, 4-Chloro-2-methoxynitrobenzene, 5-Chloro-2-nitrophenyl Methyl Ether, NSC 60112, 5-Chloro-2-nitrophenyl methyl ether, Anisole, 5-chloro-2-nitro-, Benzene, 4-chloro-2-methoxy-1-nitro-

Beschreibung

Applications 5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs (1). In addition, it is used in the synthesis of kinesin spindle protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells (2).
References (1) Mesaros, E. et al.: J. Med. Chem. (2012) 55, 115-25 (2) Parrish, C. A., et al.: J. Med. Chem. (2007) 50, 4939-50

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 187.58
• Formel: C₇H₆ClNO₃
• Farbe/Form: Neat
• SMILES: COc1cc(Cl)ccc1[N+](=O)[O-]