6-Chloropyridine-2-carboxylic Acid

CAS: 4684-94-0

Ref. TR-C380615

Produktinformation

• Name: 6-Chloropyridine-2-carboxylic Acid
• Synonyme: 6-Chloropicolinic Acid, 6-Chloro-2-pyridinecarboxylic Acid, 2-Chloropyridine-6-carboxylic Acid, NSC 51587, 2-Chloro-6-Pyridine Carboxylic Acid, 2-Chloropyridine-6-carboxylic acid, 2-Pyridinecarboxylic acid, 6-chloro-, 6-Chloro-2-Pyridine Carboxylic Acid, 6-Chloro-2-pyridinecarboxylic acid, 6-Chloro-3-picolinic acid, 6-Chloro-Picolinic Acid, 6-Chloropyridine-2-Carboxylic Acid, Picolinic acid, 6-chloro-, 6-Chloropicolinic acid

Beschreibung

Applications 6-Chloropyridine-2-carboxylic Acid is an intermediate of Sorafenib b(S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.
References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003); Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004); Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004); Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 157.55
• Formel: C₆H₄ClNO₂
• Farbe/Form: Neat
• InChl: InChI=1S/C6H4ClNO2/c7-5-3-1-2-4(8-5)6(9)10/h1-3H,(H,9,10)
• InChI Key: InChIKey=ZLKMOIHCHCMSFW-UHFFFAOYSA-N
• SMILES: O=C(O)c1cccc(Cl)n1