4-Chloro-6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

CAS: 1177447-87-8

Ref. TR-C428995

Produktinformation

• Name: 4-Chloro-6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
• Synonyme: 2,2'-Bipyrimidine, 4-chloro-6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)-
• Marke: TRC
• Beschreibung: Impurity BosentanApplications 4-Chloro-6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)-2,2'-bipyrimidine is an impurity of Bosentan (B675900). Bosentan is a mixed endothelin receptor antagonist used as a vasodilatora and an antihypertensive.References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994); Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996); Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996); Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)

Chemische Eigenschaften

• Molekulargewicht: 430.885
• Formel: C₂₁H₂₃ClN₄O₄
• Farbe/Form: Neat
• InChl: InChI=1S/C21H23ClN4O4/c1-21(2,3)29-13-12-28-20-16(30-15-9-6-5-8-14(15)27-4)17(22)25-19(26-20)18-23-10-7-11-24-18/h5-11H,12-13H2,1-4H3
• InChI Key: InChIKey=JTGXWPPVARCKAG-UHFFFAOYSA-N
• SMILES: COc1ccccc1Oc1c(Cl)nc(-c2ncccn2)nc1OCCOC(C)(C)C