Cilastatin-15N-d3

CAS: 2738376-83-3

Ref. TR-C441101

Produktinformation

• Name: Cilastatin-15N-d3
• Synonyme: (Z)-7-[(2R)-2-(15N)azanyl-2-carboxy-1,1,2-trideuterioethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid

Beschreibung

Applications (R)-2-Carboxy-2-(S)-ethyl)-thio Cilastatin is a labelled impurity of Cilastatin (C441100) which prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct.
References Finlay, K.R., et al.: Invest. Ophthalmol. Visual Sci., 24, 1147 (1983), Norrby, S.R., et al.: Antimicrob. Agents Chemother., 23, 300 (1983), Washburn, D.E., et al.: J. Antimicrob. Chemother., 12, 39 (1983),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 362.465
• Formel: C₁₆D₃H₂₃NNO₅S
• Farbe/Form: White To Off-White
• InChl: InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1/i9D2,11D,17+1
• InChI Key: InChIKey=DHSUYTOATWAVLW-IFTJZPFKSA-N
• SMILES: [2H]C([2H])(SCCCC/C=C(\NC(=O)[C@@H]1CC1(C)C)C(=O)O)C([2H])([15NH2])C(=O)O