CP-91149

CAS: 186392-40-5

Ref. TR-C781360

Produktinformation

• Name: CP-91149
• Synonyme: 5-Chloro-N-[(1S,2R)-3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide, [R-(R*,S*)]-5-Chloro-N-[3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide, 5-Chloro-N-[(2S,3R)-4-(dimethylamino)-3-hydroxy-4-oxo-1-phenyl-2-butanyl]-1H-indole-2-carboxamide, (2R,3S)-3-[(5-Chloro-1H-indol-2-yl)formamido]-2-hydroxy-N,N-dimethyl-4-phenylbutanamide, 5-chloro-N-((2S,3R)-4-(dimethylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-1H-indole-2-carboxamide

Beschreibung

Stability Hygroscopic
Applications Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression. Antitumor agent.
References Newgard, C., et al.: J. Biol. Chem., 263, 3850 (1988), Ignacio, P., et al.: Brain Res., 529, 42 (1990), Oikonomakos, N., et al.: J. Biol. Chem., 275, 34566 (2000), Pedersen, B., et al.: J. Biol. Chem., 275, 27753 (2000),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 399.8707
• Formel: C₂₁H₂₂ClN₃O₃
• Farbe/Form: Neat
• InChl: InChI=1S/C21H22ClN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1
• InChI Key: InChIKey=HINJNZFCMLSBCI-PKOBYXMFSA-N
• SMILES: CN(C)C(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1