Cyclosporin A

CAS: 59865-13-3

Ref. TR-C988900

Produktinformation

• Name: Cyclosporin A
• Synonyme: Cyclo[[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoyl]-l-2-aminobutanoyl-N-methylglycyl-N-methyl-l-leucyl-l-valyl-N-methyl-l-leucyl-l-alanyl-d-alanyl-N-methyl-l-leucyl-N-methyl-l-leucyl-N-methyl-l-valyl], ciclosporin A, 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv., Abrammune, Antibiotic S 7481F1, Arpimune ME, CICPORAL, Cicloral, Cicloral (antibiotic), Ciclosporina Germed, Cipol N, Consupren, Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl], Cyclokat, Cyclosporin, Cyclosporine, Cyclosporine A, Debio088, Equoral, Gengraf, Imusporin, NSC 290193, Neoplanta, Neoral, OL 27-400, Optimmune, Papilock Mini, Ramihyphin A, Restasis, S-Neoral, SDZ-OXL 400, Sandimmun, Sandimmun Neoral, Sandimmun Optoral, Sandimmune, Sandimmune Neoral, Sang-35, SangCyA, Sigmasporin Microoral, Zinograf ME,1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv., 1: PN: US6686454 SEQID: 1 claimed protein, 7: PN: WO2000002548 PAGE: 30 claimed protein, Ciclosporin, Ciqorin, CyclASol, Cypol-N, Abrammune, Antibiotic S 7481F1, Arpimune ME, CICPORAL, Cicloral, Cicloral (antibiotic), Ciclosporina Germed, Cipol N, Consupren, Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl], Cyclokat, Cyclosporin, Cyclosporine, Cyclosporine A, Debio088, Equoral, Gengraf, Imusporin, NSC 290193, Neoplanta, Neoral, OL 27-400, Optimmune, Papilock Mini, Ramihyphin A, Restasis, S-Neoral, SDZ-OXL 400, Sandimmun, Sandimmun Neoral, Sandimmun Optoral, Sandimmune, Sandimmune Neoral, Sang-35, SangCyA, Sigmasporin Microoral, Zinograf ME
• Marke: TRC
• Beschreibung: Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Chemische Eigenschaften

• Molekulargewicht: 1202.61
• Formel: C₆₂H₁₁₁N₁₁O₁₂
• Farbe/Form: Neat
• InChl: InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
• InChI Key: InChIKey=PMATZTZNYRCHOR-CGLBZJNRSA-N
• SMILES: C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C