N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine

CAS: 912569-84-7

Ref. TR-D199035

Produktinformation

• Name: N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine
• Synonyme: S-Me-DM1
• Marke: TRC
• Beschreibung: Applications N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine is an active metabolite of Maytansine (M197940), inhibits in vitro polymerization of tubulin and is used in the treatment of advanced breast cancer.References Remillard, S., et. al.: Science, 189, 1002 (1975); Prota, A.E., et. al.: P. Natl. Acad. Sci. USA, 111, 13817 (2014)

Chemische Eigenschaften

• Molekulargewicht: 752.31
• Formel: C₃₆H₅₀ClN₃O₁₀S
• Reinheit: >90%
• Farbe/Form: Neat
• InChl: InChI=1S/C36H50ClN3O10S/c1-20-11-10-12-27(47-8)36(45)19-26(48-34(44)38-36)21(2)32-35(4,50-32)28(49-33(43)22(3)39(5)29(41)13-14-51-9)18-30(42)40(6)24-16-23(15-20)17-25(46-7)31(24)37/h10-12,16-17,21-22,26-28,32,45H,13-15,18-19H2,1-9H3,(H,38,44)/b12-10+,20-11+/t21-,22+,26+,27-,28+,32+,35+,36+/m1/s1