(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic Acid Triethylammonium Chloride Salt

CAS: 1015073-43-4

Ref. TR-D232080

Produktinformation

• Name: (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic Acid Triethylammonium Chloride Salt
• Synonyme: PSI 7411 Triethylammonium Chloride Salt
• CAS: 1015073-43-4

Beschreibung

Applications (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic Acid Triethylammonium Chloride Salt is an intermediate in the synthesis of (2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine 5'-​Triphosphate Triethylammonium Salt (D235370), an impurity of Sofosbuvir (P839640). Sofosbuvir is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 340.20 + 137.65
• Formel: C₁₀H₁₄FN₂O₈P•C₆H₁₆ClN
• Farbe/Form: white solid
• SMILES: CC[NH+](CC)CC.C[C@@]1(F)C(O)[C@H](COP(=O)(O)O)O[C@H]1n1ccc(=O)[nH]c1=O.[Cl-]