Desethyl Azilsartan Medoxomil

CAS: 1417576-00-1

Ref. TR-D289258

Produktinformation

• Name: Desethyl Azilsartan Medoxomil
• Synonyme: 3-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2,3-dihydro-2-oxo-1H-benzimidazole-4-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester, 2-Oxo-3-[2'-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-biphenyl-4-yl methyl]-3H-benzoimidazole-4-carboxylic acid 5-methyl-2-oxo-{1,3}dioxol-4-ylmethyl ester, Azilsartan Impurity 16

Beschreibung

Applications Desethyl Azilsartan Medoxomil is an impurity from the synthesis of Azilsartan Medoxomil (A926910). Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).
References Radl, S., et al.: Org. Process. Res. Dev., 17), 77-86 (2013); Baker, W. & White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 540.48
• Formel: C₂₈H₂₀N₄O₈
• Farbe/Form: Neat
• InChl: InChI=1S/C28H20N4O8/c1-15-22(39-28(36)38-15)14-37-25(33)20-7-4-8-21-23(20)32(26(34)29-21)13-16-9-11-17(12-10-16)18-5-2-3-6-19(18)24-30-27(35)40-31-24/h2-12H,13-14H2,1H3,(H,29,34)(H,30,31,35)
• InChI Key: InChIKey=MZPRTKPTVHPGEW-UHFFFAOYSA-N
• SMILES: Cc1oc(=O)oc1COC(=O)c1cccc2[nH]c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c12