N-Desmethyl Diltiazem Hydrochloride

CAS: 130606-60-9

Ref. TR-D291610

Produktinformation

• Name: N-Desmethyl Diltiazem Hydrochloride
• Synonyme: Diltiazem Hydrochloride Imp. D (EP), Diltiazem Imp. D (EP), (2S,3S)-2-(4-Methoxyphenyl)-5-[2-(methylamino)ethyl]-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl Acetate Hydrochloride, Diltiazem Hydrochloride Imp. D (EP) as Hydrochloride, Diltiazem Hydrochloride Impurity D as Hydrochloride, Diltiazem Impurity D as Hydrochloride, N-DemethyldiltiazemN-Monodesmethyldiltiazem,HCl, N-Monodesmethyldiltiazem, (2S-cis)-3-(Acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-5-[2-(methylamino)ethyl]-1,5-benzothiazepin-4(5H)-one Monohydrochloride, N-Demethyldiltiazem

Beschreibung

Impurity Dilitiazem EP Impurity D
Stability Hygroscopic
Applications N-Desmethyl Diltiazem Hydrochloride (Dilitiazem EP Impurity D) is a metabolite of Diltiazem (D460620), an antianginal and an antihypertensive pharmaceutical. Diltiazem regulates calcium release from intracellular stores in neutrophils.
References Li, R., et al.: J. Med. Chem., 35, 3246 (1992),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 436.95
• Formel: C₂₁H₂₄N₂O₄S·ClH
• Farbe/Form: White To Off-White
• InChl: InChI=1S/C21H24N2O4S.ClH/c1-14(24)27-19-20(15-8-10-16(26-3)11-9-15)28-18-7-5-4-6-17(18)23(21(19)25)13-12-22-2;/h4-11,19-20,22H,12-13H2,1-3H3;1H/t19-,20+;/m1./s1
• InChI Key: InChIKey=GIYQYIVUHPJUHS-FDOHDBATSA-N
• SMILES: CNCCN1C(=O)[C@H](OC(C)=O)[C@H](c2ccc(OC)cc2)Sc2ccccc21.Cl