N-Desmethyl-N-methoxycarbonyl-10-hydroxycodeinone

Ref. TR-D291915

Produktinformation

• Name: N-Desmethyl-N-methoxycarbonyl-10-hydroxycodeinone
• Synonyme: methyl (4S,7aR,12bS)-13-hydroxy-9-methoxy-7-oxo-1,2,4,4a,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-3-carboxylate

Beschreibung

Applications N-Desmethyl-N-methoxycarbonyl-10-hydroxycodeinone is an impurity in the synthesis of N-Allyldihydro-8,10,14-trihydroxynormorphinone (A549610), an impurity of Naloxone (HCl salt, N285000) which is a specific opioid antagonist and narcotic antagonist.
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967); McNicholas, L.F., et al.: Drugs, 27, 81 (1984); Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985); Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 357.357
• Formel: C₁₉H₁₉NO₆
• Farbe/Form: Neat
• InChl: InChI=1S/C19H19NO6/c1-24-12-6-3-9-13-16(12)26-17-11(21)5-4-10-14(15(9)22)20(18(23)25-2)8-7-19(10,13)17/h3-6,10,14-15,17,22H,7-8H2,1-2H3/t10?,14-,15?,17-,19-/m0/s1
• InChI Key: InChIKey=YROJUFVAPXYPBR-GJLDWQSPSA-N
• SMILES: COC(=O)N1CC[C@]23c4c5ccc(OC)c4O[C@H]2C(=O)C=CC3[C@H]1C5O