(1R,2R)-rel-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenyl-cyclopropanecarboxamide

CAS: 907205-34-9

Ref. TR-D446973

Produktinformation

• Name: (1R,2R)-rel-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenyl-cyclopropanecarboxamide
• Synonyme: (1R,2S)-rel-2-(1,3-Dioxoisoindolin-2-yl)-N,N-diethyl-1-phenylcyclopropanecarboxamide

Beschreibung

Applications (1R,2R)-rel-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenyl-cyclopropanecarboxamide is an intermediate in synthesizing rac,trans-Milnacipran Hydrochloride (M344625), which is an impurity of rac-Milnacipran Hydrochloride (M344600), an antidepressant and a selective norepinephrine and serotonin reuptake inhibitor.
References Moret, C., et al.: Neuropharmacology, 24, 1211 (1985); Palmier, C., et al.: Eur. J. Clin. Pharmacol., 37, 235 (1989); Spencer, C.M., et al.: Drugs, 56, 405 (1998)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 362.42
• Formel: C₂₂H₂₂N₂O₃
• Farbe/Form: Off-White to Pale Yellow Solid
• InChl: InChI=1S/C22H22N2O3/c1-3-23(4-2)21(27)22(15-10-6-5-7-11-15)14-18(22)24-19(25)16-12-8-9-13-17(16)20(24)26/h5-13,18H,3-4,14H2,1-2H3/t18-,22+/m0/s1
• InChI Key: InChIKey=GXFOWOAFIPHIRU-PGRDOPGGSA-N
• SMILES: CCN(CC)C(=O)[C@@]1(c2ccccc2)C[C@@H]1N1C(=O)c2ccccc2C1=O