1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-[2-[(2-hydroxybenzoyl)amino]ethyl] Ester

CAS: 92565-34-9

Ref. TR-D450715

Produktinformation

• Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-[2-[(2-hydroxybenzoyl)amino]ethyl] Ester
• Synonyme: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Ethyl 2-[(2-hydroxybenzoyl)amino]ethyl Ester
• Marke: TRC
• Beschreibung: Applications 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-[2-[(2-hydroxybenzoyl)amino]ethyl] Ester is a potential anti-hypertensive drug. 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-[2-[(2-hydroxybenzoyl)amino]ethyl] Ester is functionally and structurally related to Manidipine Dihydrochloride (M164015) and Nifedipine (N457000). Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Nifedipine is used as an antihypertensive and antianginal drug. Nifedipine is a dihydorpyridine calcium channel blocker.References Meguro, K., et al.: Chem. Pharm. Bull., 33, 3787 (1985); Mizuno, K., et al.: Curr. Ther. Res., 52, 248 (1992); Hosaka, S., et al.: Chem. Pharma. Bulletin., 55, 793 (2007); Ali, S.L., et al.: Anal. Profiles Drug Subs., 18, 221 (1989); Soons, P.A., et al.: J. Pharm. Biomed. Anal., 9, 475 (1991); Brown, M.J., et al.: Lancet, 356, 366 (2000)

Chemische Eigenschaften

• Molekulargewicht: 509.508
• Formel: C₂₆H₂₇N₃O₈
• Farbe/Form: Neat
• InChl: InChI=1S/C26H27N3O8/c1-4-36-25(32)21-15(2)28-16(3)22(23(21)17-8-7-9-18(14-17)29(34)35)26(33)37-13-12-27-24(31)19-10-5-6-11-20(19)30/h5-11,14,23,28,30H,4,12-13H2,1-3H3,(H,27,31)
• SMILES: CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCCNC(=O)c2ccccc2O)C1c1cccc([N+](=O)[O-])c1