6a,​9a-​Difluoro-11b,21-dihydroxy-pregna-1,4,16-triene-3,20-dione

CAS: 1270039-29-6

Ref. TR-D451745

Produktinformation

• Name: 6a,​9a-​Difluoro-11b,21-dihydroxy-pregna-1,4,16-triene-3,20-dione
• Synonyme: (6alpha,11beta)-6,9-Difluoro-11,21-dihydroxy-pregna-1,4,16-triene-3,20-dione, (6alpha,11beta)-6,9-Difluoro-11,21-dihydroxypregna-1,4,16-triene-3,20-dione
• CAS: 1270039-29-6

Beschreibung

Applications 6α,​9α-​Difluoro-11β,21-dihydroxy-pregna-1,4,16-triene-3,20-dione is an impurity of the drug Difluprednate (D445925). Difluprednate is a corticosteroid (derivative of prednisolone), approved for the treatment of post-operative ocular inflammation.
References Kapp, A., et al.: J. Allergy and Clin. Immunol., 110, 277 (2002); Yasueda, S., et al.: J. Pharm. Biomed. Anal., 30, 1735 (2003); Yamaguchi, M., et al.: Int. J. Pharm., 301, 121 (2005)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 378.41
• Formel: C₂₁H₂₄F₂O₄
• Farbe/Form: Neat
• InChl: InChI=1S/C21H24F2O4/c1-19-9-18(27)21(23)14(12(19)3-4-13(19)17(26)10-24)8-16(22)15-7-11(25)5-6-20(15,21)2/h4-7,12,14,16,18,24,27H,3,8-10H2,1-2H3/t12-,14-,16-,18-,19-,20-,21-/m0/s1
• InChI Key: InChIKey=KVEOPUITANBHFN-FXZCQDAKSA-N
• SMILES: C[C@]12C[C@H](O)[C@@]3(F)[C@@H](C[C@H](F)C4=CC(=O)C=C[C@@]43C)[C@@H]1CC=C2C(=O)CO