trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene

CAS: 57404-88-3

Ref. TR-D452280

Produktinformation

• Name: trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene
• Synonyme: Benzo[a]pyrene-7,8-diol, 7,8-dihydro-, (7R,8R)-rel-, Benzo[a]pyrene-7,8-diol, 7,8-dihydro-, trans-, rel-(7R,8R)-7,8-Dihydrobenzo[a]pyrene-7,8-diol, (±)-trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, Benzo[a]pyrene-trans-7,8-dihydrodiol, trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, trans-7,8-Dihydrobenzo[a]pyrene-7,8-diol, trans-Benzo[a]pyrene-7,8-dihydrodiol, (±)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene, Benzo[a]pyrene-7,8-diol, 7,8-dihydro-, (7R,8R)-rel-, Benzo[a]pyrene-7,8-diol, 7,8-dihydro-, trans-, benzo[a]pyrene-9,10-diol, 9,10-dihydro-, (9S,10S)-

Beschreibung

Applications trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene is a metabolite of Benzopyrene (B205800). Benzo[a]pyrene (B205800), a prototypic PAH, is metabolized by cytochrome P 450 1A1/1B1. (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene (D452280) undergoes further P 4501A1/1B1-mediated metabolism to a carcinogen, which forms DNA-adducts primarily with 2'-deoxyguanosine. A carcinogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gelhaus, S. et al: Chem. Res. Toxicol., 24, 89 (2011); Belvedere, G. et al.: Biochem. Pharmacol., 29, 1693 (1980); Jennette, K. et al.: Biochem. Pharmacol., 28, 338 (1979); Yagi, H. et al.: J. Am. Chem. Soc., 99, 2358 (1977)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 286.32
• Formel: C₂₀H₁₄O₂
• Reinheit: >90%
• Farbe/Form: Neat
• InChl: InChI=1S/C20H14O2/c21-17-9-8-14-15-7-6-12-3-1-2-11-4-5-13(19(15)18(11)12)10-16(14)20(17)22/h1-10,17,20-22H/t17-,20-/m0/s1