(E)-4-(Dimethylamino)but-2-enoyl Chloride-d6

CAS: 1056149-69-9

Ref. TR-D456337

Produktinformation

• Name: (E)-4-(Dimethylamino)but-2-enoyl Chloride-d6
• Synonyme: (E)-4-[bis(trideuteriomethyl)amino]but-2-enoyl chloride

Beschreibung

Applications (E)-4-(Dimethylamino)but-2-enoyl Chloride-d6 is an intermediate used in the synthesis of Afatinib-d6 (A355303), which is the d6 labeled analogue of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References Schroeder, J., et al.: PCT Int. Appl. WO 2007085638 A1 20070802. Aug 2, 2007;

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 153.64
• Formel: C₆D₆H₄ClNO
• Farbe/Form: Neat
• InChl: InChI=1S/C6H10ClNO/c1-8(2)5-3-4-6(7)9/h3-4H,5H2,1-2H3/b4-3+/i1D3,2D3
• InChI Key: InChIKey=BOTUQNGRMXZOTH-XDMLVRQJSA-N
• SMILES: [2H]C([2H])([2H])N(C/C=C/C(=O)Cl)C([2H])([2H])[2H]