4,5-Dimethoxy-1-(aminomethyl)benzocyclobutane

CAS: 73344-75-9

Ref. TR-D461855

Produktinformation

• Name: 4,5-Dimethoxy-1-(aminomethyl)benzocyclobutane
• Synonyme: 1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine, 3,4-Dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine, (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine, 1-[3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl]methanamine, 3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-methanamine, C-(3,4-Dimethoxy-Bicyclo[4.2.0]Octa-1(6),2,4-Trien-7-Yl)-Methylamine, [3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl]methanamine, Bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine, 3,4-dimethoxy-

Beschreibung

Applications 4,5-Dimethoxy-1-(aminomethyl)benzocyclobutane is used in the synthesis of ent-Ivabradine Hydrochloride (I940505), which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Also an antianginal.
References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994); Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998); Borer, J.S., et al.: Circulation, 107, 817 (2003); DiFrancesco, D., et al.: Drugs, 64, 1757 (2004)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 193.24
• Formel: C₁₁H₁₅NO₂
• Farbe/Form: Neat
• InChl: InChI=1S/C11H15NO2/c1-13-10-4-7-3-8(6-12)9(7)5-11(10)14-2/h4-5,8H,3,6,12H2,1-2H3
• InChI Key: InChIKey=JDZSBHBIJDIACW-UHFFFAOYSA-N
• SMILES: COc1cc2c(cc1OC)C(CN)C2