Dimethyl Fumarate

CAS: 624-49-7

Ref. TR-D464965

Produktinformation

• Name: Dimethyl Fumarate
• Synonyme: AZL-O 211089, BG 00012, NSC 167432, NSC 25942, trans-1,2-Ethylenedicarboxylic Acid Dimethyl Ester, Fumaric acid dimethyl ester,Dimethyl Fumarate, 2-Butenedioic acid (2E)-, 1,4-dimethyl ester (ACI), 2-Butenedioic acid (2E)-, dimethyl ester (9CI), 2-Butenedioic acid (E)-, dimethyl ester (ZCI), Fumaric acid, dimethyl ester (6CI, 8CI), (2E)-2-Butenedioic acid dimethyl ester, (E)-2-Butenedioic acid dimethyl ester, (E)-But-2-enedioic acid dimethyl ester, Allomaleic acid dimethyl ester, BG 12, Boletic acid dimethyl ester, Dimethyl (E)-2-butenedioate, Dimethyl (E)-but-2-enedioate, Dimethyl (E)-butenedioate, Dimethyl trans-ethylenedicarboxylate, Marclerosis, Methyl fumarate, Panaclar, Skilarence, Tecfidera, Tecfira
• Marke: TRC
• Beschreibung: Applications Dimethyl fumarate is the methyl ester form of Fumaric Acid (F500380), and is a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis. Dimethyl fumarate is effective in treating multiple sclerosis by mediating the activation of the nuclear 1 factor (Nrf2) antioxidant response pathway, resulting in neuroprotective effects. Dimethyl fumarate is also used in cycloaddition reactions involving ylides, benzenes and amino acids. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Albrecht, P., et al.: J. Neuroinflammation, 9, 2094 (2012); Chen, X. et al.: J. Am. Chem. Soc., 130, 5652 (2008); Gold, R., et al.: New Engl. J Med., 367, 1098 (2012); Gothelf, A. et al.: Angew. Chem., Int. Ed., 41, 4236 (2002); Schmidt, T., et al.: Bioorg. Med. Chem., 15, 333 (2007)

Chemische Eigenschaften

• Molekulargewicht: 144.13
• Formel: C₆H₈O₄
• Farbe/Form: White
• InChl: InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+
• InChI Key: InChIKey=LDCRTTXIJACKKU-ONEGZZNKSA-N
• SMILES: COC(=O)/C=C/C(=O)OC