N-[(1S)-1-[(Dimethylamino)carbonyl]-3-methylbutyl]-carbamic Acid 1,1-Dimethylethyl Ester

CAS: 72080-89-8

Ref. TR-D470788

Produktinformation

• Name: N-[(1S)-1-[(Dimethylamino)carbonyl]-3-methylbutyl]-carbamic Acid 1,1-Dimethylethyl Ester
• Synonyme: (S)-tert-Butyl (1-(dimethylamino)-4-methyl-1-oxopentan-2-yl)carbamate, 1,1-Dimethylethyl N-[(1S)-1-[(dimethylamino)carbonyl]-3-methylbutyl]carbamate

Beschreibung

Applications N-[(1S)-1-[(Dimethylamino)carbonyl]-3-methylbutyl]-carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of (S)-2-Amino-4-methyl-1-((S)-2-methyloxiran-2-yl)pentan-1-one Trifluoroacetate Salt which is an impurity of carfilzomib (C183460). Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 258.36
• Formel: C₁₃H₂₆N₂O₃
• Farbe/Form: Neat
• InChl: InChI=1S/C13H26N2O3/c1-9(2)8-10(11(16)15(6)7)14-12(17)18-13(3,4)5/h9-10H,8H2,1-7H3,(H,14,17)/t10-/m0/s1
• InChI Key: InChIKey=UIJSURSVLVISBO-UBKIQSJTSA-N
• SMILES: O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1O