Dimethyl (1-Diazo-2-oxopropyl)phosphonate

CAS: 90965-06-3

Ref. TR-D471815

Produktinformation

• Name: Dimethyl (1-Diazo-2-oxopropyl)phosphonate
• Synonyme: Bestmann-Ohira Reagent, 1-Diazo-1-(dimethyl phosphono)acetone, Bestmann Reagent, Dimethyl (1-Azo-2-oxopropyl)phosphonate, Dimethyl (1-azoacetonyl)phosphonate, Dimethyl (acetyldiazomethyl)phosphonate, Ohira-Bestmann Phosphonate Ohira-Bestmann Reagent, Ohira's Reagent, a-Azido-a-(Dimethyl phosphono)acetone, (1-Diazo-2-oxopropyl)phosphonic acid dimethyl ester, Nnyv1&Po&O1&O1, Phosphonic acid, P-(1-diazo-2-oxopropyl)-, dimethyl ester
• CAS: 90965-06-3

Beschreibung

Applications Dimethyl (1-Diazo-2-oxopropyl)phosphonate is a chemical reagent used in the synthesis of vacuolar type ATPase inhibitor Bafilomycin (B110000), which is used to counter age-related diseases. Also used in the synthesis of novel fluorinated derivatices of TSP 18 kDa ligand SSR18075 which are promising candidates for drug development or PET probes for in viv neuroinflammation imaging.
References Shibata, H. et al.: Chem. Asian J., 10, 915 (2015); Damont, A. et al.: Eur. j. Med. Chem., 101, 736 (2015);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 192.11
• Formel: C₅H₉N₂O₄P
• Farbe/Form: Neat
• SMILES: COP(=O)(OC)C(=[N+]=[N-])C(C)=O