Dimethyloxaloylglycine

CAS: 89464-63-1

Ref. TR-D476325

Produktinformation

• Name: Dimethyloxaloylglycine
• Synonyme: N-[(Methoxycarbonyl)methyl]oxamic Acid Methyl Ester, N-(methoxyoxoacetyl)glycine Methyl Ester, DMOG, glycine, N-(2-methoxy-1,2-dioxoethyl)-, methyl ester
• CAS: 89464-63-1

Beschreibung

Applications DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models (1nM). DMOG also inhibits FIH (factor inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/Kg).
References Milkiewicz, M., et al.: J. Physiol., 560, 21 (2004), Koivunen, P., et al.: J. Biol. Chem., 279, 9899 (2004, Asikainen, T.M., et al.: Free Radic. Biol. Med., 38, 1002 (2005),Asikainen, T.M., et al.: Proc. Natl. Acad. Sci. USA, 102, 10212 (2005), Ockaili, R., et al.: Am. J. Physiol. Heart Circ. Physiol., 289, H522 (2005)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 175.14
• Formel: C₆H₉NO₅
• Farbe/Form: White to Light Pink Solid
• InChl: InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
• InChI Key: InChIKey=BNJOZDZCRHCODO-UHFFFAOYSA-N
• SMILES: COC(=O)CNC(=O)C(=O)OC