N-[1-(2,3-Dioleyloxy)propyl]-N,N,N-trimethylammonium Chloride

CAS: 104162-48-3

Ref. TR-D484000

Produktinformation

• Name: N-[1-(2,3-Dioleyloxy)propyl]-N,N,N-trimethylammonium Chloride
• Synonyme: N,N,N-Trimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanaminium Chloride, N-(1-(2,3-Dioleyloxy)propyl)-N,N,N-trimethylammonium chloride, 1-Propanaminium, N,N,N-trimethyl-2,3-bis(9-octadecenyloxy)-, chloride, (Z,Z)-, 2,3-bis[(Z)-octadec-9-enoxy]propyl-trimethyl-ammonium chloride

Beschreibung

Applications Small unilamellar liposomes containing DOTMA interact spontaneously with DNA to form lipid-DNA complexes with 100% entrapment of DNA. Facilitates fusion of the complex with the plasma membrane of tissue culture cells, resulting in both uptake and expression of the DNA. Effective technique for transient and stable expression of transfected DNA.
References Zhu., N., et al.: Science, 261, 209 (1993), Wang, J., et al.: Pharmazie, 62, 723 (2007), Shur, J., et al.: J. Pharm. Sci., 97, 4857 (2008),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 670.57
• Formel: C₄₂H₈₄ClNO₂
• Farbe/Form: Neat
• InChl: InChI=1S/C42H84NO2.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-44-41-42(40-43(3,4)5)45-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,42H,6-19,24-41H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-
• SMILES: CCCCCCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC/C=C\CCCCCCCC.[Cl-]