Estradiol 6-N3-Adenine (~90%)

Ref. TR-E668590

Produktinformation

• Name: Estradiol 6-N3-Adenine (~90%)
• Synonyme: (8R,9S,13S,14S,17S)-6-(6-Amino-3H-purin-3-yl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
• Marke: TRC
• Beschreibung: Applications Estradiol 6-N3-Adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogeneous initiators of various human cancers, such as breast & prostate.References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)

Chemische Eigenschaften

• Molekulargewicht: 405.493
• Formel: C₂₃H₂₇N₅O₂
• Reinheit: ~90%
• Farbe/Form: Neat
• InChl: InChI=1S/C23H27N5O2/c1-23-7-6-14-13-3-2-12(29)8-16(13)18(9-15(14)17(23)4-5-19(23)30)28-11-27-21(24)20-22(28)26-10-25-20/h2-3,8,10-11,14-15,17-19,29-30H,4-7,9,24H2,1H3/t14-,15-,17+,18?,19+,23+/m1/s1
• InChI Key: InChIKey=ABUVIBYOTRBZKW-WPVFROKISA-N
• SMILES: C[C@]12CC[C@@H]3c4ccc(O)cc4C(n4cnc(N)c5ncnc4-5)C[C@H]3[C@@H]1CC[C@@H]2O