6-Ethyl-4-(1-piperazinyl)thieno[2,3-d]pyrimidine Hydrochloride

CAS: 502648-93-3

Ref. TR-E898795

Produktinformation

• Name: 6-Ethyl-4-(1-piperazinyl)thieno[2,3-d]pyrimidine Hydrochloride
• Synonyme: 6-ethyl-4-(piperazin-1-yl)thieno[2,3-d]pyrimidine dihydrogen chloride
• Marke: TRC
• Beschreibung: Applications 6-Ethyl-4-(1-piperazinyl)thieno[2,3-d]pyrimidine Hydrochloride is an intermediate used in the synthesis of 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride (E926745), which is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.References Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012)

Chemische Eigenschaften

• Molekulargewicht: 248.35 + 2(36.46)
• Formel: C₁₂H₁₆N₄S•2(HCl)
• Farbe/Form: Neat
• InChl: InChI=1S/C12H16N4S.2ClH/c1-2-9-7-10-11(14-8-15-12(10)17-9)16-5-3-13-4-6-16;;/h7-8,13H,2-6H2,1H3;2*1H