(Z)-Ethyl 4-(2-(tert-Butoxy)-2-oxoethoxy)-2-(2-chlorobenzylidene)-3-oxobutanoate

Ref. TR-E951860

Produktinformation

• Name: (Z)-Ethyl 4-(2-(tert-Butoxy)-2-oxoethoxy)-2-(2-chlorobenzylidene)-3-oxobutanoate
• Synonyme: ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-3-oxobutanoate
• Marke: TRC
• Beschreibung: Applications (Z)-Ethyl 4-(2-(tert-butoxy)-2-oxoethoxy)-2-(2-chlorobenzylidene)-3-oxobutanoate is an intermediate for the synthesis of O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine (D289480), which is the metablolite of Amlodipine (A633495), a long-acting calcium channel blocker that is commonly used as an anti-hypertensive in the treatment of cardiovascular conditions.References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995)

Chemische Eigenschaften

• Molekulargewicht: 382.835
• Formel: C₁₉H₂₃ClO₆
• Farbe/Form: Neat
• InChl: InChI=1S/C19H23ClO6/c1-5-25-18(23)14(10-13-8-6-7-9-15(13)20)16(21)11-24-12-17(22)26-19(2,3)4/h6-10H,5,11-12H2,1-4H3/b14-10-
• InChI Key: InChIKey=DQIJJTDIMMDERW-UVTDQMKNSA-N
• SMILES: CCOC(=O)/C(=C\c1ccccc1Cl)C(=O)COCC(=O)OC(C)(C)C