Flavopiridol Hydrochloride

CAS: 131740-09-5

Ref. TR-F373000

Produktinformation

• Name: Flavopiridol Hydrochloride
• Synonyme: 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one;hydrochloride, (3R,4S)-4-[2-(2-chlorophenyl)-5,7-dihydroxy-4-oxo-4H-chromen-8-yl]-3-hydroxy-1-methylpiperidinium chloride, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one hydrochloride, 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, cis-(-)-, 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride, 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1), Alvocidib Hydrochloride, Flavopiridol Hcl, HL 275 hydrochloride, HMR 1275 hydrochloride, Hl 275, L 86-8275 hydrochloride, L 868275 hydrochloride, L-86-8276, NSC-649890, (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidinyl]-4h-1-benzopyran-4-one hydrochloride, Mdl 107826A, Nsc 649890, rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride

Beschreibung

Applications An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells.
References Senderowicz, A.M., et al.: J. Clin. Oncol., 16, 2986 (1998), Thomas, J.P., et al.: Cancer Chemother. Pharmacol., 50, 465 (2002), Raju, U., et al.: Cancer Res., 63, 3263 (2003), Pumfery, A., et al.: Curr. Pharm. Des., 12, 1949 (2006),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 438.30
• Formel: C₂₁H₂₀ClNO₅·ClH
• Farbe/Form: Light Yellow
• InChl: InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m1./s1
• InChI Key: InChIKey=LGMSNQNWOCSPIK-UHFFFAOYSA-N
• SMILES: CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1.Cl