4-Fluoro-Alpha-(2-methyl-1-oxopropyl)-Gamma-oxo-N,Beta-diphenyl-benzenebutanamide

CAS: 125971-96-2

Ref. TR-F593700

Produktinformation

• Name: 4-Fluoro-Alpha-(2-methyl-1-oxopropyl)-Gamma-oxo-N,Beta-diphenyl-benzenebutanamide
• Synonyme: 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide, 4-Fluoro-alpha-(2-methyl-1-oxopropyl)-gamma-oxo-N,beta-diphenylbenzenebutanamide, (4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzene butane amide(M-4), 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide, 4-Fluoro-Alpha-(2-Methyl-1-Oxopropyl)-Gamma-Oxo-N,Beta-Diphenylbenzene Butaneamide, 4-Fluoro-alpha-(2-methyl-1-oxopropyl)-gamma-oxo-N,bata-diphenylbenzene butaneamide (M4), 4-Fluoro-α-(2-methyl-1-oxopropyl)-γ-oxo-N,β-diphenylbenzenebutanamide, 4-Fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzene butanamide, 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzene butane amide, 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzene butane amideIsobutyrylacetic acid methyl ester, 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzene butaneamide, Benzenebutanamide, 4-fluoro-α-(2-methyl-1-oxopropyl)-γ-oxo-N,β-diphenyl-, Fr Dvyr&Yvmr&Vy1&1, M-4, M-4(atovastatin's intermediate), benzenebutanamide, 4-fluoro-alpha-(2-methyl-1-oxopropyl)-gamma-oxo-N,beta-diphenyl-

Beschreibung

Impurity Atorvastatin Diketo Amide Impurity
Applications An Atorvastatin intermediate. Atorvastatin is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Winters, R., et al.: J. Med. Chem., 36, 1735 (1993), Hagmann, W., et al.: Bioorg. Med. Chem. Lett., 10, 1975 (2000), Istvan, E., et al.: Science, 292, 1160 (2001)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 417.47
• Formel: C₂₆H₂₄FNO₃
• Farbe/Form: White To Off-White
• InChl: InChI=1S/C26H24FNO3/c1-17(2)24(29)23(26(31)28-21-11-7-4-8-12-21)22(18-9-5-3-6-10-18)25(30)19-13-15-20(27)16-14-19/h3-17,22-23H,1-2H3,(H,28,31)
• InChI Key: InChIKey=SNPBHOICIJUUFB-UHFFFAOYSA-N
• SMILES: CC(C)C(=O)C(C(=O)Nc1ccccc1)C(C(=O)c1ccc(F)cc1)c1ccccc1