N-Formyl Apixaban

CAS: 1351611-14-7

Ref. TR-F696855

Produktinformation

• Name: N-Formyl Apixaban
• Synonyme: N-Formyl-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

Beschreibung

Applications N-Formyl Apixaban is derived from Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 487.51
• Formel: C₂₆H₂₅N₅O₅
• Farbe/Form: Neat
• InChl: InChI=1S/C26H25N5O5/c1-36-20-11-9-19(10-12-20)31-24-21(23(28-31)25(34)27-16-32)13-15-30(26(24)35)18-7-5-17(6-8-18)29-14-3-2-4-22(29)33/h5-12,16H,2-4,13-15H2,1H3,(H,27,32,34)
• InChI Key: InChIKey=RRAFWRVOUFGSEW-UHFFFAOYSA-N
• SMILES: COc1ccc(-n2nc(C(=O)NC=O)c3c2C(=O)N(c2ccc(N4CCCCC4=O)cc2)CC3)cc1