20(R)-Ginsenoside Rg3

CAS: 38243-03-7

Ref. TR-G387625

Produktinformation

• Name: 20(R)-Ginsenoside Rg3
• Synonyme: (3ß,12ß,20R)-12,20-Dihydroxydammar-24-en-3-yl 2-O-ß-D-Glucopyranosyl-ß-D-glucopyranoside, (20R)-Ginsenoside Rg3, (20R)-Propanaxadiol, (20S)-Propanaxadiol, (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(10R,12S,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxa, (3Beta,12Beta)-12,20-Dihydroxydammar-24-En-3-Yl 2-O-Beta-D-Glucopyranosyl-Beta-D-Glucopyranoside, (3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranoside, (3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→2)-β-<smallcap>D</span>-glucopyranoside, (5xi,8xi,9xi,12alpha,14beta,20R)-12,20-dihydroxylanost-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside, (8xi,9xi,12alpha,14beta,17alpha)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,14-tetramethylgonan-3-yl 2-O-[3-deoxy-3-(hydroxymethyl)-beta-D-glucopyranosyl]-beta-D-glucopyranoside, 20(R)-Ginsenoside Rg₃, 20(R)-Propanaxadiol, 20(S)-Ginsenoside-Rg3, 20R-Ginsenoside Rg3, Beta-D-Glucopyranoside,(3-Beta,12-Beta)-12,20-Dihydroxydammar-24-En-3-Yl2-O-B, Dammar-24-Ene-12-Beta,20-Diol,3-Beta-((2-O-Beta-D-Glucopyranosyl-Beta-D-Gluc, Dammar-24-ene-12β,20-diol, 3β-[(2-O-β-D-, Eta-D-Glucopyranosyl-, Ginsenoside rg3(R), Opyransoyl)Oxy)-, R-Ginsenoside Rg₃, beta-D-Glucopyranoside,(3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl, β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl 2-O-β-<smallcap>D</span>-glucopyranosyl-

Beschreibung

Applications 20(R)-Ginsenoside Rg3 causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated. Elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells. in vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase isoforms and in vivo inhibition of tumor angiogenesis of lung cancer.
References Liu, Y., et al.: Chengdu Yixueyuan Xuebao, 9, 4 (2014); Liu, Y., et al.: Linchuang Junyi Zazhi, 42, 1138 (2014), Kim, D., et al.: Toxicol. Lett., 259, 1 92016); Geng, L., et al.: Zhonghua Zhongyiyao Zazhi, 29, 601 (2014)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 785.01
• Formel: C₄₂H₇₂O₁₃
• Farbe/Form: Neat
• InChl: InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42+/m0/s1
• InChI Key: InChIKey=RWXIFXNRCLMQCD-CZIWJLDFSA-N
• SMILES: CC(C)=CCC[C@@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@]12C