Glufosfamide

CAS: 132682-98-5

Ref. TR-G596880

Produktinformation

• Name: Glufosfamide
• Synonyme: D 19575, Glucosylifosfamide Mustard, 1-[N,N'-bis(2-Chloroethyl)phosphorodiamidate] β-D-Glucopyranose, (2S,3R,4S,5S,6R)-2-Bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,5-triol, 1-O-{bis[(2-chloroethyl)amino]phosphoryl}-beta-D-glucopyranose, Glucosylifosfamide mustard, Glufosfamide,B-D-Glucopyranose, 1-(N,N'-Bis(2-Chloroethyl)Phosphorodiamidate)-, β-<span class="text-smallcaps">D</span>-Glucopyranose, 1-[N,N′-bis(2-chloroethyl)phosphorodiamidate], β-D-Glucopyranose, 1-[N,N′-bis(2-chloroethyl)phosphorodiamidate]

Beschreibung

Applications Glufosfamide is an alkylating cytotoxic agent with increased antitumor selectivity and active transmembrane transport mechanism, that belongs to the oxazaphosphorine class. It is an attractive new agent for cancer therapy in humans.
References Pohl, J., et al.: Cancer Chemother. Pharmacol., 35, 364 (1995); Mazur, L., et al.: Anticancer Drugs, 22, 488 (2011);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 383.163
• Formel: C₁₀H₂₁Cl₂N₂O₇P
• Farbe/Form: Neat
• InChl: InChI=1S/C10H21Cl2N2O7P/c11-1-3-13-22(19,14-4-2-12)21-10-9(18)8(17)7(16)6(5-15)20-10/h6-10,15-18H,1-5H2,(H2,13,14,19)/t6-,7-,8+,9-,10+/m1/s1
• InChI Key: InChIKey=PSVUJBVBCOISSP-SPFKKGSWSA-N
• SMILES: O=P(NCCCl)(NCCCl)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O