GSK-626616

CAS: 1025821-33-3

Ref. TR-G797853

Produktinformation

• Name: GSK-626616
• Synonyme: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone

Beschreibung

Applications GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.
References Wippich, Frank., et al.: Cell., 152, 791(2013); Corona, John A., et al.: Org. Process Res. Dev., 14, 712 (2010)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 401.27
• Formel: C₁₈H₁₀Cl₂N₄OS
• Farbe/Form: Yellow
• InChl: InChI=1S/C18H10Cl2N4OS/c19-11-2-1-3-12(20)16(11)23-18-24-17(25)15(26-18)9-10-4-5-13-14(8-10)22-7-6-21-13/h1-9H,(H,23,24,25)/b15-9-
• InChI Key: InChIKey=RJPNRXFBYZVRIB-DHDCSXOGSA-N
• SMILES: O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1