4-​Hydroxy-​7-​methoxy-6-​quinolinecarboxamide​

CAS: 2110414-05-4

Ref. TR-H211040

Produktinformation

• Name: 4-​Hydroxy-​7-​methoxy-6-​quinolinecarboxamide​
• Synonyme: 4-hydroxy-7-methoxyquinoline-6-carboxamide

Beschreibung

Applications 4-​Hydroxy-​7-​methoxy-6-​quinolinecarboxamide​ is useful in the synthetic preparation of Lenvatinib (L329400(P)) with high purity. Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.
References Liu, S., et al.: Faming Zhuanli Shenqing (2020), CN 111377865 A; Matsui, J., et al.: Clin. Cancer Res., 14, 5459 (2008); Gild, M., et al.: Nature Rev. Endocrinol., 7, 617 (2011)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 218.209
• Formel: C₁₁H₁₀N₂O₃
• Farbe/Form: Neat
• InChl: InChI=1S/C11H10N2O3/c1-16-10-5-8-6(4-7(10)11(12)15)9(14)2-3-13-8/h2-5H,1H3,(H2,12,15)(H,13,14)
• InChI Key: InChIKey=ZXSGIBJYMYHCMM-UHFFFAOYSA-N
• SMILES: COc1cc2nccc(O)c2cc1C(N)=O