19-Hydroxyandrostendione

CAS: 510-64-5

Ref. TR-H801500

Produktinformation

• Name: 19-Hydroxyandrostendione
• Synonyme: (8R,9S,10S,13S,14S)-10-(hydroxymethyl)-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione, (8Xi,10Xi,13Xi)-19-Hydroxyandrost-4-Ene-3,17-Dione, 19-Hydroxy-4-Androstene-3,17-Dione, 19-Hydroxyandrost-4-Ene-3,17-Dione, 19-Hydroxyandrostenedione, 4-Androsten-19-Ol-3,17-Dione, 4-Androstene-3,17-Dione-19-0L, 4-Androstene-3,17-Dione-19-Ol, Androst-4-en-19-ol-3,17-dione, Androst-4-ene-3,17-dione, 19-hydroxy-, Androst-4-ene-3,17-dione-19-ol, NSC 74233

Beschreibung

Applications 19-Hydroxyandrostendione is a novel substituted estrogen as aromatase inhibitor. It induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olactory receptor.
References Polan, M., et al.: J. Clin. Endocrinol. Metab., 70, 480 (1990), Kawasaki, T., et al.: Clin. Exp. Rheumatol., 18, 743, (2000), Castagnetta, L., et al.: Clin. Cancer Res., 8, 3146 (2002); Frontiers in Oncology, May 2018, vol. 8, article 162; https://doi.org/10.3389/fonc.2018.00162; Gen. Eng. and Biotech. News (https://www.genengnews.com/gen-news-highlights/could-prostate-cancer-be-treated-with-aromatherapy-in-the-future/81255862)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 302.41
• Formel: C₁₉H₂₆O₃
• Farbe/Form: Off White Solid
• InChl: InChI=1S/C19H26O3/c1-18-8-7-16-14(15(18)4-5-17(18)22)3-2-12-10-13(21)6-9-19(12,16)11-20/h10,14-16,20H,2-9,11H2,1H3/t14-,15-,16-,18-,19+/m0/s1
• InChI Key: InChIKey=XGUHPTGEXRHMQQ-BGJMDTOESA-N
• SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43CO)[C@@H]1CCC2=O