17a-Hydroxy-21-chloro-9b,11b-epoxy-16a-methylpregna-1,4-diene-3,20-dione-d5

CAS: 83881-08-7

Ref. TR-H915452

Produktinformation

• Name: 17a-Hydroxy-21-chloro-9b,11b-epoxy-16a-methylpregna-1,4-diene-3,20-dione-d5
• Synonyme: (4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-(2-chloroacetyl-d2)-7-hydroxy-4a,6a,8-trimethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one-1,11,11-d3
• Marke: TRC
• Beschreibung: Applications 17α-Hydroxy-21-chloro-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione-d5 is an intermediate in synthesizing Mometasone-d5 (M489997), an Isotope labelled analogue of Mometasone (M489995), a potent topical corticosteroid. Mometasone has potent antiinflammatory activity and is used in the treatment of dermatological disorders.References Schulz, M. et al.: Pharm. Zeit., 139, 28 (1994); Prakash, A. et al.: Drugs, 55, 145 (1998)

Chemische Eigenschaften

• Molekulargewicht: 395.93
• Formel: C₂₂H₂₂D₅ClO₄
• Farbe/Form: White
• InChl: InChI=1S/C22H27ClO4/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)22(15)18(27-22)10-20(16,3)21(12,26)17(25)11-23/h6-7,9,12,15-16,18,26H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19+,20+,21+,22-/m1/s1/i4D2,9D,11D2
• InChI Key: InChIKey=NXJYMGPXHVQNOT-UHFFFAOYSA-N
• SMILES: CC1(C)OB(c2ccc3c(c2)NC(=O)C3)OC1(C)C