4β-Hydroxy Cholesterol

CAS: 17320-10-4

Ref. TR-H917980

Produktinformation

• Name: 4β-Hydroxy Cholesterol
• Synonyme: (3S,4R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,4-diol, (3β,4β)-Cholest-5-ene-3,4-diol, 3β,4β-Dihydroxycholest-5-ene, 4β-Hydroxycholesterol, 5-Cholesten-3-Beta, 4-Beta-Diol, Cholest-5-Ene-3,4-Diol, Cholest-5-ene-3,4-diol, (3β,4β)-, Cholest-5-ene-3β,4β-diol, cis-3,4-Dihydroxy-Δ⁵-cholestene, cis-Δ⁵-Cholestene-3,4-diol

Beschreibung

Applications A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.
References Breuer, O., et al.: J. Lipid Res., 36, 2275 (1995), Pikuleva, I., et al.: J. Biol. Chem., 273, 18153 (1998), Chawla, A., et al.: Science, 294, 1866 (2001), Bodin, K., et al.: J. Biol. Chem., 276, 38685 (2001),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 402.65
• Formel: C₂₇H₄₆O₂
• Farbe/Form: White To Light Beige
• InChl: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1
• InChI Key: InChIKey=CZDKQKOAHAICSF-JSAMMMMSSA-N
• SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4[C@@H](O)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C