4-Hydroxy Darunavir

CAS: 313682-97-2

Ref. TR-H931765

Produktinformation

• Name: 4-Hydroxy Darunavir
• Synonyme: Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-[(4-hydroxyphenyl)methyl]propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester, Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-[(4-hydroxyphenyl)methyl]propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester (9CI)

Beschreibung

Applications 4-Hydroxy Darunavir is a metabolite of Darunavir (D193500), a novel inhibitor of human immunodeficiency virus protease and used in the treatment of HIV infection. It is a COVID19-related research product.
References Vermeir, M., et al.: Drug. Meta. Disp., 37, 809 (2009); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 563.66
• Formel: C₂₇H₃₇N₃O₈S
• Farbe/Form: Neat
• InChl: InChI=1S/C27H37N3O8S/c1-17(2)14-30(39(34,35)21-9-5-19(28)6-10-21)15-24(32)23(13-18-3-7-20(31)8-4-18)29-27(33)38-25-16-37-26-22(25)11-12-36-26/h3-10,17,22-26,31-32H,11-16,28H2,1-2H3,(H,29,33)/t22-,23-,24+,25-,26+/m0/s1
• InChI Key: InChIKey=SNQVQNQWAPHMDK-MMBLVWGISA-N
• SMILES: CC(C)CN(C[C@@H](O)C(Cc1ccc(O)cc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)S(=O)(=O)c1ccc(N)cc1