(E)-4-Hydroxy-N-desmethyl Tamoxifen

CAS: 114828-90-9

Ref. TR-H938495

Produktinformation

• Name: (E)-4-Hydroxy-N-desmethyl Tamoxifen
• Synonyme: 4-[(1E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol, E-Endoxifen
• CAS: 114828-90-9

Beschreibung

Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 373.49
• Formel: C₂₅H₂₇NO₂
• Farbe/Form: Neat
• InChl: InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24+
• InChI Key: InChIKey=MHJBZVSGOZTKRH-OCOZRVBESA-N
• SMILES: CC/C(=C(/c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1