(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)

CAS: 112093-28-4

Ref. TR-H938500

Produktinformation

• Name: (Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)
• Synonyme: N-Desmethyl-4-Hydroxy Tamoxifen
• Marke: TRC
• Beschreibung: Stability Light Sensitive, Temperature SensitiveApplications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),

Chemische Eigenschaften

• Molekulargewicht: 373.49
• Formel: C₂₅H₂₇NO₂
• Farbe/Form: Neat
• InChl: InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24-
• InChI Key: InChIKey=MHJBZVSGOZTKRH-IZHYLOQSSA-N
• SMILES: CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1