2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

Ref. TR-H939800

Produktinformation

• Name: 2-Hydroxyisoquinoline-1,3(2H,4H)-dione
• Synonyme: 2-hydroxy-4H-isoquinoline-1,3-dione, 1,3(2H,4H)-Isoquinolinedione, 2-hydroxy-

Beschreibung

Applications 2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. Its interaction with Mg2+ and Mn2+ was investigated using different spectroscopic techniques and it was reported that 2-hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+ but a 1:2 complex with Mn2+. Antiviral agent.
References Greenwald, J., et al.: Biochemistry, 38, 8892 (1999), Tramontano, E., et al.: Antiviral Res., 65, 117 (2005), Schultz, S., et al.: Virus Res., 134, 86 (2008), Williams, P., et al.: Bioorg. Med. Chem. Lett., 22, 6754 (2010),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 177.16
• Formel: C₉H₇NO₃
• Farbe/Form: Neat
• InChl: InChI=1S/C9H7NO3/c11-8-5-6-3-1-2-4-7(6)9(12)10(8)13/h1-4,13H,5H2
• InChI Key: InChIKey=ZXAICCBFIBBVAR-UHFFFAOYSA-N
• SMILES: O=C1Cc2ccccc2C(=O)N1O