6-Hydroxy-L-DOPA

CAS: 27244-64-0

Ref. TR-H941725

Produktinformation

• Name: 6-Hydroxy-L-DOPA
• Synonyme: 3-(3,4,6-Trihydroxyphenyl)-alanine
• Marke: TRC
• Beschreibung: Impurity Levodopa EP Impurity A; Levodopa USP Related Compound AStability HygroscopicApplications 6-Hydroxy-L-DOPA (Levodopa EP Impurity A; Levodopa USP Related Compound A) is the 6-hydroxy derivative of the amino acid L-DOPA (D533751) with neurotoxic properties. Studies show that exogenously administered 6-Hydroxy-L-DOPA is biotransformed by amino acid decarboxylase to the highly potent and catecholamine-selective neurotoxin, 6-Hydroxydopamine. The treatment of 6-Hydroxy-L-DOPA in rats resulted in the stimulation of acetylcholinesterase.References Jaim-Etcheverry, G. et al.: Brain Res., 100, 699 (1975); Kostrzewa, R.M. et al.: Amino Acids, 14, 175 (1998); Berthet, A. et al.: J. Neurosci., 29, 4829 (2009)

Chemische Eigenschaften

• Molekulargewicht: 213.19
• Formel: C₉H₁₁NO₅
• Farbe/Form: Brown To Black
• InChl: InChI=1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)/t5-/m0/s1
• InChI Key: InChIKey=YLKRUSPZOTYMAT-YFKPBYRVSA-N
• SMILES: N[C@@H](Cc1cc(O)c(O)cc1O)C(=O)O