2-Hydroxy-estrone-6-N3-adenine (90%)

CAS: 912671-65-9

Ref. TR-H942165

Produktinformation

• Name: 2-Hydroxy-estrone-6-N3-adenine (90%)
• Synonyme: 6-(6-Amino-3H-purin-3-yl)-2,3-dihydroxy-estra-1,3,5(10)-trien-17-one

Beschreibung

Applications 2-Hydroxy-estrone-6-N3-adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogenous initiators of various human cancers, such as breast & prostate.
References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 419.48
• Formel: C₂₃H₂₅N₅O₃
• Reinheit: 90%
• Farbe/Form: Neat
• InChl: InChI=1S/C23H25N5O3/c1-23-5-4-11-12-7-17(29)18(30)8-14(12)16(6-13(11)15(23)2-3-19(23)31)28-10-27-21(24)20-22(28)26-9-25-20/h7-11,13,15-16,29-30H,2-6,24H2,1H3/t11-,13-,15+,16?,23+/m1/s1
• InChI Key: InChIKey=ILMIYAFNYQGIRH-RIGYJOQTSA-N
• SMILES: C[C@]12CC[C@@H]3c4cc(O)c(O)cc4C(n4cnc(N)c5ncnc4-5)C[C@H]3[C@@H]1CCC2=O