N-(2-Hydroxyethyl) Chlorambucil

CAS: 27171-89-7

Ref. TR-H942955

Produktinformation

• Name: N-(2-Hydroxyethyl) Chlorambucil
• Synonyme: Benzenebutanoic acid, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, Butyric acid, 4-[p-[(2-chloroethyl)(2-hydroxyethyl)amino]phenyl]- (8CI), 4-[(2-Chloroethyl)(2-hydroxyethyl)amino]benzenebutanoic acid, 4-[4-N-(2-Chloroethyl)-N-(2-hydroxyethyl)aminophenyl]bu

Beschreibung

Applications N-(2-Hydroxyethyl) Chlorambucil is a degradation product of Chlorambucil (C325050); an alkylating agent used as a chemotherapy drug in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Hodgkin's lymphoma (NHL) and Hodgkin's disease.
References Cogia, A., et al.: Leuk. Lymph., 53, 1961 (2012); Tonino, S.H., et al.: Leuk. Lymph., 53, 1785 (2012); Smolej, L., et al.: Curr. Pharma. Design., 18, 3399 (2012); Ehrsson, H., et al.: J. Pharm. Sci., 69, 1091 (1980)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 285.767
• Formel: C₁₄H₂₀ClNO₃
• Farbe/Form: Neat
• InChl: InChI=1S/C14H20ClNO3/c15-8-9-16(10-11-17)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7,17H,1-3,8-11H2,(H,18,19)
• InChI Key: InChIKey=SFCORMODVLBZLW-UHFFFAOYSA-N
• SMILES: O=C(O)CCCc1ccc(N(CCO)CCCl)cc1