4-Hydroxy-7,8-didehydro-deepoxy-naloxone-d5

Ref. TR-H946252

Produktinformation

• Name: 4-Hydroxy-7,8-didehydro-deepoxy-naloxone-d5
• Synonyme: (1R,9R,10S)-3,4,10-trihydroxy-17-(1,1,2,3,3-pentadeuterioprop-2-enyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6,11-tetraen-13-one

Beschreibung

Applications 4-Hydroxy-7,8-didehydro-deepoxy-naloxone-d5 is labelled 4-Hydroxy-7,8-didehydro-deepoxy-naloxone (H946250) which is a possible impurity of Naloxone (N285000, HCl salt) which is a specific opioid antagonist.
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967); McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985); Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 332.405
• Formel: C₁₉D₅H₁₆NO₄
• Farbe/Form: Neat
• InChl: InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-11-13(21)5-6-19(18,24)15(20)10-12-3-4-14(22)17(23)16(12)18/h2-6,15,22-24H,1,7-11H2/t15-,18-,19-/m1/s1/i1D2,2D,8D2
• InChI Key: InChIKey=KJAKWCUUMSIRBJ-XTXKUREKSA-N
• SMILES: [2H]C([2H])=C([2H])C([2H])([2H])N1CC[C@]23CC(=O)C=C[C@@]2(O)[C@H]1Cc1ccc(O)c(O)c13