(S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester

CAS: 177036-78-1

Ref. TR-H946295

Produktinformation

• Name: (S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester
• Synonyme: (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid Methyl Ester, Ambrisentan Hydroxyester Impurity, Methyl (2S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoate, (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester, (S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoic Acid Methyl Ester (Ambrisentan)

Beschreibung

Impurity Ambrisentan Hydroxyester Impurity
Applications (S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester is an impurity in the synthesis of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive. (Ambrisentan Hydroxyester Impurity)
References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 286.32
• Formel: C₁₇H₁₈O₄
• Farbe/Form: Neat
• InChl: InChI=1S/C17H18O4/c1-20-16(19)15(18)17(21-2,13-9-5-3-6-10-13)14-11-7-4-8-12-14/h3-12,15,18H,1-2H3/t15-/m1/s1
• InChI Key: InChIKey=BEPLSLADXOJCBY-OAHLLOKOSA-N