2-Hydroxymethyl Rilpivirine

CAS: 1798429-64-7

Ref. TR-H949130

Produktinformation

• Name: 2-Hydroxymethyl Rilpivirine
• Synonyme: 4-[[4-[[4-[(E)-2-Cyanoethen-1-yl]-2-(hydroxymethyl)-6-methylphenyl]amino]pyrimidin-2-yl]amino]benzonitrile, 2-Hydroxymethylrilpivirine

Beschreibung

Applications 2-Hydroxymethyl Rilpivirine is an analog of Rilpivirine (R509800) a novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
References Sun, et al.: J. Med. Chem., 41, 4648 (1998), Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001); Jorgensen, W. et al.: J. Am. Chem. Soc., 133, 15685 (2011);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 382.42
• Formel: C₂₂H₁₈N₆O
• Farbe/Form: Neat
• InChl: InChI=1S/C22H18N6O/c1-15-11-17(3-2-9-23)12-18(14-29)21(15)27-20-8-10-25-22(28-20)26-19-6-4-16(13-24)5-7-19/h2-8,10-12,29H,14H2,1H3,(H2,25,26,27,28)