iCRT-14

CAS: 677331-12-3

Ref. TR-I163900

Produktinformation

• Name: iCRT-14
• Synonyme: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione, iCRT14

Beschreibung

Applications A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
References Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011); Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 375.44
• Formel: C₂₁H₁₇N₃O₂S
• Farbe/Form: Neat
• InChl: InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
• InChI Key: InChIKey=NCSHZXNGQYSKLR-UNOMPAQXSA-N
• SMILES: Cc1cc(/C=C2\SC(=O)N(c3ccccc3)C2=O)c(C)n1-c1cccnc1