IDRA-21

CAS: 22503-72-6

Ref. TR-I232500

Produktinformation

• Name: IDRA-21
• Synonyme: 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide, 2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide, Idra 21

Beschreibung

Applications IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer's disease.
References (1) Malkova, L, et al.: Neuropharmacology. 60, 1262 (2011)(2) Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999)(3) Sun, Y., et al.: Nature, 417, 245 (2002) (4) Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 232.69
• Formel: C₈H₉ClN₂O₂S
• Farbe/Form: Neat
• InChl: InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
• InChI Key: InChIKey=VZRNTCHTJRLTMU-UHFFFAOYSA-N
• SMILES: CC1Nc2ccc(Cl)cc2S(=O)(=O)N1