IMD 0354

CAS: 978-62-1

Ref. TR-I268650

Produktinformation

• Name: IMD 0354
• Synonyme: 5-Chloro-a,a,a,a',a',a'-hexafluoro-3',5'-salicyloxylidide N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide, Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-, Tcmdc-125465

Beschreibung

Applications IMD 0354 is an inhibitor of IKK β (IKK-2) and blocks Iκβα phosphorylation in the NF-κB pathway. IMD 0354 might also have therapeutic efficacy in the treatment of human mesothelioma.
References Nishikawa, S., et al.: Cancer Med., 3, 416 (2014); Tanka., A., et al.: Blood, 105, 2324 (2005); Sugita. A., et al.: Int. Arch. Allergy Immunol, 148, 186 (2009); Kamon, J.M., et al.:Biochem., Biophys, Res. Commun,, 323, 242 (2004); Onai, et al.: Cardiovasc. Res., 63, 51 (2004)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 383.67
• Formel: C₁₅H₈ClF₆NO₂
• Farbe/Form: Neat
• InChl: InChI=1S/C26H42O6/c1-17-15-18-19(21(2)9-10-24(16-25(17,21)27)31-13-14-32-24)5-7-22(3)20(18)6-8-26(22,28)23(4)29-11-12-30-23/h17-20,27-28H,5-16H2,1-4H3/t17-,18-,19-,20-,21-,22+,25-,26+/m1/s1
• InChI Key: InChIKey=WOEHXCDLEYXISO-NMRJUBPYSA-N
• SMILES: C[C@@H]1C[C@H]2[C@H]3CC[C@@](O)(C4(C)OCCO4)[C@@]3(C)CC[C@H]2[C@@]2(C)CCC3(C[C@@]12O)OCCO3