Indomethacin

CAS: 53-86-1

Ref. TR-I641000

Produktinformation

• Name: Indomethacin
• Synonyme: 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid, 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid, 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid, 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid, 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid, Amuno, Argun, Artracin, Artrinovo, Artrivia, Bonidin, Bonidon Gel, Catlep, Chibro-Amuno, Chrono-Indicid, Chrono-Indocid 75, Confortid, Dolcidium, Dolcidium PL, Dolovin, Durametacin, Elmetacin, Endol, Flam, Globa, Idomethine, Imbrilon, Inacid, Indacin, Indo-Phlogont, Indo-Rectolmin, Indo-Tablinen, IndoRich, Indocid, Indocid (pharmaceutical), Indocin, Indocollyre, Indomecol, Indomed, Indomee, Indometacin, Indometacine, Indomethacine, Indomethine, Indomod, Indonol, Indoptic, Indoptol, Indorektal, Indoxen, Indren, Inflazon, Infrocin, Innamit, Inteban, Inteban SP, Lausit, Metacen, Metartril, Methazine, Metindol, Mezolin, Mikametan, Mobilan, N-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid, NSC 77541, Reumacide, Rheumacin LA, Sadoreum, Tannex, Vital Vitacid, Vonum, [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid,1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl- (9CI, ACI), 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (ACI), Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl- (8CI), 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid, 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid, 2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid, Aconip, IMC, Indocin IV, Indocine, MeSH ID: D007213, Microcid
• Marke: TRC
• Beschreibung: Impurity Acemetacin EP Impurity BApplications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)

Chemische Eigenschaften

• Molekulargewicht: 357.79
• Formel: C₁₉H₁₆ClNO₄
• Farbe/Form: Beige
• InChl: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
• InChI Key: InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
• SMILES: COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1