Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate

CAS: 2206827-14-5

Ref. TR-I872280

Produktinformation

• Name: Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate
• Synonyme: Isopropyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate

Beschreibung

Applications Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate is an impurity in the synthesis of Sorafenib (S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.
References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003), Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004), Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004), Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 329.35
• Formel: C₁₇H₁₉N₃O₄
• Farbe/Form: Neat
• InChl: InChI=1S/C17H19N3O4/c1-11(2)23-17(22)20-12-4-6-13(7-5-12)24-14-8-9-19-15(10-14)16(21)18-3/h4-11H,1-3H3,(H,18,21)(H,20,22)
• InChI Key: InChIKey=OTZYFALTTCYAFP-UHFFFAOYSA-N
• SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)OC(C)C)cc2)ccn1